Early detection is the key to successful treatment and maximum longevity in dogs. Some of the possible causes of this condition are trauma, an inherited recessive gene, or intrauterine infection. Renal Dysplasia begins during fetal development.

Possible signs can include polydipsia and polyuria (excessive thirst and frequent urination). Diagnostic testing should include a complete blood panel, chemistry panel, urinalysis and urine: protein: creatine ratio. If blood and urine results warrant additional testing an abdominal ultrasound with biopsy will confirm a diagnosis of renal dysplasia.

Once a diagnosis is made, medical management becomes essential. This will include dietary adjustments with AAFCO recommendations. This will include a diet with increased vitamin B, Protein and f 5.6g/100kcal, calcium of 300mg/kcal, phosphorus 25mg/100kcal, sodium 20mg/100kcal. Additionally, EPA and DHA of 140mg/kg are beneficial. These recommendations are for growing puppies and should be adjusted for adult dogs. Treats should be no more than 10% off the daily calorie intake and can include fresh fruits such as blueberries.

Bloodwork should be reevaluated every 3-6 months during the early stages. This should also include blood pressure rechecks as well. Normal blood pressure is 120-130mmHg, but can be as high as 160mmHg if the dog is stressed. Three readings should be taken and averaged for an accurate result. In the later stages if the disease, Blood work should be reevaluated every 2-3 months. Consulting an Internal Medicine Veterinarian is recommended to adequately manage this condition.

Fluid Therapies including diuresis and Sub Cutaneous fluids may be necessary for managing this condition and symptoms increase and blood values rise. Medications may also be recommended to help with quality of life. These include phosphorus binders like Epakitin, pepcid and famotidine for nausea and benazepril or amlodipine for blood pressure. Phosphorus binders and blood pressure medications will ease the stress on the kidneys. The anti-nausea medications will help with appetite.

Currently there are no mastiff specific DNA tests for Renal Dysplasia.

Helpful Resources

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Updated: 11/12/2024